| week | favorite | underdog | spread |
| 15 | BUCCANEERS | falcons | 4.5 |
| 15 | ravens | BENGALS | 2.5 |
| 15 | bills | PATRIOTS | 1.5 |
| 15 | BEARS | browns | 7.5 |
| 15 | CHIEFS | chargers | 4.5 |
| 15 | EAGLES | raiders | 11.5 |
| 15 | TEXANS | cardinals | 9.5 |
| 15 | JAGUARS | jets | 12.5 |
| 15 | GIANTS | commanders | 2.5 |
| 15 | 49ERS | titans | 12.5 |
| 15 | RAMS | lions | 5.5 |
| 15 | packers | BRONCOS | 2.5 |
| 15 | SEAHAWKS | colts | 13.5 |
| 15 | panthers | SAINTS | 2.5 |
| 15 | COWBOYS | vikings | 5.5 |
| 15 | STEELERS | dolphins | 3.5 |
| Home teams in CAPS; Spreads: BettingData.com | |||
| Byes: | No byes; remaining weeks full 16 gm schedule | ||
| NOTE: | TNF: BUCCANEERS v. falcons | ||
| NOTE: | MNF: STEELERS v. dolphins | ||
| NOTE: | |||