| week | favorite | underdog | spread |
| 18 | steelers | RAVENS | 3.5 |
| 18 | COLTS | texans | 1.5 |
| 18 | jaguars | TITANS | 3.5 |
| 18 | SAINTS | falcons | 3.5 |
| 18 | BENGALS | browns | 6.5 |
| 18 | LIONS | vikings | 3.5 |
| 18 | PATRIOTS | jets | 1.5 |
| 18 | buccaneers | PANTHERS | 4.5 |
| 18 | PACKERS | bears | 3.5 |
| 18 | eagles | GIANTS | 5.5 |
| 18 | seahawks | CARDINALS | 2.5 |
| 18 | cowboys | COMMANDERS | 13.5 |
| 18 | RAIDERS | broncos | 3.5 |
| 18 | CHARGERS | chiefs | 3.5 |
| 18 | 49ERS | rams | 4.5 |
| 18 | bills | DOLPHINS | 2.5 |
| Home teams in CAPS; Spreads: BettingData.com | |||
| Byes: | Byes ended week 14 - full 16 game schedule | ||
| NOTE: | No Thursday game in week 18 | ||
| NOTE: | Sat: pit v. BAL; IND v. hou | ||
| NOTE: | No Monday night game this week | ||